HETEROCYCLIC INHIBITORS OF HUMAN-LEUKOCYTE ELASTASE - 3-HYDROXYPYRIDAZOPYRIMIDINE, 3-HYDROXYPYRIDOPYRIMIDINE AND 3-HYDROXYQUINAZOLINE-2,4(1H,3H)DIONE DERIVATIVES

被引:4
作者
GROUTAS, WC
CASTRISOS, JC
STANGA, MA
KUANG, RZ
VENKATARAMAN, R
EPP, JB
BRUBAKER, MJ
CHONG, LS
机构
[1] Department of Chemistry, Wichita State University, Wichita
关键词
D O I
10.1016/S0960-894X(00)80307-8
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Several heterocyclic compounds derived from 3-hydroxypyridazopyrimidine-(I), 3-hydroxypyridopyrimidine-(II) and 3-hydroxyquinazoline-2,4(1H,3H)diones-(III) have been found to be time-dependent irreversible inhibitors of human leukocyte elastase.
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页码:1163 / 1168
页数:6
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