THE SUPRAMAMMILLARY NUCLEUS - IS IT NECESSARY FOR THE MEDIATION OF HIPPOCAMPAL THETA-RHYTHM

被引：82

作者：

THINSCHMIDT, JS

KINNEY, GG

KOCSIS, B

机构：

[1] FISONS PHARMACEUT,DIV BIOL,DEPT PHARMACOL,ROCHESTER,NY 14623

[2] NATL INST NEUROSURG,H-1145 BUDAPEST,HUNGARY

来源：

NEUROSCIENCE | 1995年 / 67卷 / 02期

关键词：

D O I：

10.1016/0306-4522(95)00045-K

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recent evidence suggests that the supramammillary nucleus of the posterior hypothalamus serves as an important relay in a brainstem to septum/hippocampus pathway involved in the generation of hippocampal theta rhythm. In order to examine the role of the supramammillary nucleus as a possible relay/mediator of hippocampal theta rhythm, electrolytic lesions and procaine injections were administered to the supramammillary nucleus of freely moving and urethane-anesthetized rats: respectively. In the urethane-anesthetized rat, it was found that procaine injections attenuated both the frequency and amplitude of theta rhythm elicited by stimulation of the pontine reticular formation. These data suggest that the pontine reticular elicitation of hippocampal theta rhythm is mediated through connections with the supramammillary nucleus. However, it was found that lesions of the supramammillary nucleus failed to produce significant changes in the hippocampal electroencephalogram of freely moving animals. Several explanations concerning this apparent discrepancy are discussed. The most compelling is that multiple brainstem to septum/hippocampus pathways may serve to generate or facilitate the generation of theta rhythm in the freely moving animal. The present report demonstrates that the supramammillary nucleus plays a questionable role in the mediation of hippocampal electroencephalogram signals which are thought to be important for mnemonic processes.

引用

页码：301 / 312

页数：12

共 47 条

[1]

Assaf, Miller, The role of a raphe serotonin system in the control of septal unit activity and hippocampal desynchronization, Neuroscience, 3, pp. 539-550, (1978)

[2]

Bland, The physiology and pharmacology of hippocampal formation theta rhythms, Prog. Neurobiol., 26, pp. 1-54, (1986)

[3]

Bland, Colom, Oddie, Dorsomedial-posterior hypothalamic influences on the septo-hippocampal pathway in the generation of hippocampal theta, Soc. Neurosci. Abstr., 17, (1992)

[4]

DeRyck, Teitelbaum, Neocortical and hippocampal EEG in normal and lateral hypothalamic-damaged rats, Physiol. Behav., 20, pp. 403-409, (1978)

[5]

Eichenbaum, Otto, Cohen, The hippocampus—What does it do?, Behav. neural Biol., 57, pp. 2-36, (1992)

[6]

Farris, Sainsbury, The role of pontis oralis in the generation of RSA activity in the hippocampus of the guinea pig, Physiol. Behav., 47, pp. 1193-1199, (1990)

[7]

George, Haslett, Jenden, A cholinergic mechanism in the brainstem reticular formation: induction of paradoxical sleep, Int. J. Neuropharmac., 3, pp. 541-552, (1964)

[8]

Huerta, Lisman, Heightened synaptic plasticity of hippocampal CA1 neurons during a cholinergically induced rhythmic state, Nature, 364, pp. 723-725, (1993)

[9]

Jurkowlaniec, Trojniar, Ozorowska, Tokarski, Differential effect of the damage to the lateral hypothalamic area on hippocampal theta rhythm during waking and paradoxical sleep, Acta neurobiol., 49, pp. 153-169, (1989)

[10]

Kawamura, Domino, Hippocampal slow (“arousal”) wave activation in the rostral midbrain transected cat, Electroenceph. clin. Neurophysiol., 25, pp. 471-485, (1968)

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