FAILURE OF OPIATES TO REVERSE DOPAMINE-INHIBITION OF PROLACTIN SECRETION INVITRO

被引：25

作者：

MACLEOD, RM ^{[1
]}

机构：

[1] UNIV VIRGINIA,SCH MED,DEPT INTERNAL MED,CHARLOTTESVILLE,VA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1979年 / 60卷 / 2-3期

关键词：

Dopamine; Enkephalin; Morphine; Prolactin;

D O I：

10.1016/0014-2999(79)90227-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

To identify the site of action of opiate-induced prolactin elevation, in vitro rat hemipotuitary incubations were performed in the presence of morphine, met-enkephalin, ala2-met5-enkephalinamide and dopamine (DA) and combinations of opiate with the catecholamine. No opiate stimulated prolactin release directly nor did any opiate block of the inhibitory effect of DA. We conlcude that this opiate endocrine action is not mediated at a pituitary level but may involved interference with hypothalamic DA release. © 1979.

引用

页码：253 / 255

页数：3

共 11 条

[1] [Anonymous], FRONT NEUROENDOCRIN
[2] EVIDENCE THAT METHADONE STIMULATES PROLACTIN-RELEASE BY DOPAMINE RECEPTOR BLOCKADE
CLEMENS, JA
SAWYER, BD
[J]. ENDOCRINE RESEARCH COMMUNICATIONS, 1974, 1 (04): : 373 - 378
[3] DEYO S, 1979, FED PROC, V38, pA714
[4] EFFECT OF MORPHINE ON THE DOPAMINE INHIBITION OF PITUITARY PROLACTIN-RELEASE INVITRO
ENJALBERT, A
RUBERG, M
FIORE, L
ARANCIBIA, S
PRIAM, M
KORDON, C
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1979, 53 (02) : 211 - 212
[5] ENCEPHALIN-STIMULATED PROLACTIN-RELEASE
LIEN, EL
FENICHEL, RL
GARSKY, V
SARANTAKIS, D
GRANT, NH
[J]. LIFE SCIENCES, 1976, 19 (06) : 837 - 840
[6] BETA-ENDORPHIN INVITRO INHIBITION OF STRIATAL DOPAMINE RELEASE
LOH, HH
BRASE, DA
SAMPATHKHANNA, S
MAR, JB
WAY, EL
LI, CH
[J]. NATURE, 1976, 264 (5586) : 567 - 568
[7] MITTLER JC, 1978, LEU ENKEPHALIN MODUL, P350
[8] EFFECTS OF MORPHINE ON SERUM PROLACTIN LEVELS OF MORPHINE-TOLERANT AND NONTOLERANT MALE RATS AND ON INVITRO RELEASE OF PITUITARY PROLACTIN
MURAKI, T
TOKUNAGA, Y
[J]. JAPANESE JOURNAL OF PHARMACOLOGY, 1978, 28 (06) : 803 - 810
[9] STIMULATION INVIVO OF SECRETION OF PROLACTIN AND GROWTH-HORMONE BY BETA-ENDORPHIN
RIVIER, C
VALE, W
LING, N
BROWN, M
GUILLEMIN, R
[J]. ENDOCRINOLOGY, 1977, 100 (01) : 238 - 241
[10] TOLIS G, 1975, J CLIN ENDOCR METAB, V41, P797, DOI 10.1210/jcem-41-4-797

← 1 2 →