FACTORS INFLUENCING PRECIPITATION OF PH-ADJUSTED BUPIVACAINE SOLUTIONS

被引：10

作者：

BOURGET, P ^{[1
]}

BONHOMME, L ^{[1
]}

BENHAMOU, D ^{[1
]}

机构：

[1] UNIV PARIS SUD,HOSP ANTOINE BECLERE,DEPT ANESTHIOL,CLAMART,FRANCE

来源：

JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS | 1990年 / 15卷 / 03期

关键词：

D O I：

10.1111/j.1365-2710.1990.tb00375.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Solutions of bupivacaine precipitate when bicarbonate is added. This limits the clinical use of pH‐adjustment in optimizing bupivacaine activity. In this study four different bupivacaine solutions were studied with the addition of sodium bicarbonate at 4° or 20°C. Bupivacaine concentrations remained unchanged after pH‐adjustment. Least crystallization was observed with bupivacaine solutions containing a small amount of sodium bicarbonate and stored at 4°C. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：197 / 204

页数：8

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