EFFECTS OF ORALLY-ADMINISTERED DRUGS ON DYNAMIC VISCOELASTICITY OF HUMAN NASAL MUCUS

被引：36

作者：

MAJIMA, Y

HIRATA, K

TAKEUCHI, K

HATTORI, M

SAKAKURA, Y

机构：

[1] Dept. of Otorhinolaryngology, Mie University, School of Medicine, Mie 514, 2-174 Edobashi, Tsu

来源：

AMERICAN REVIEW OF RESPIRATORY DISEASE | 1990年 / 141卷 / 01期

关键词：

D O I：

10.1164/ajrccm/141.1.79

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

The effects of orally administered drugs on rheologic properties of nasal mucus were investigated in adult chronic sinusitis patients. The elastic modulus G' and the dynamic viscosity η' of nasal mucus were determined by an oscillating sphere magnetic rheometer. Both G' and η' values of the mucus before drug administration were much higher than optimal viscoelasticity for mucocilliary transport. Norfloxacin, an antibacterial agent, reduced the G' but not the η'. The results indicate that some of the orally administered mucokinetic agents can improve the abnormal rheologic properties of nasal mucus in chronic sinusitis.

引用

页码：79 / 83

页数：5

共 27 条

[1] DRUGS AFFECTING CLEARANCE OF MIDDLE-EAR SECRETIONS - A PERSPECTIVE FOR THE MANAGEMENT OF OTITIS-MEDIA WITH EFFUSION [J].