INDUCTION OF GENE CONVERSION IN DIPLOID YEAST BY CHEMICALS - CORRELATION WITH MUTAGENIC ACTION AND ITS RELEVANCE IN GENOTOXICITY SCREENING

被引：39

作者：

MURTHY, MSS

机构：

[1] Division of Radiological Protection, Bhabha Atomic Research Centre, Bombay, 4000 085, Trombay

来源：

MUTATION RESEARCH | 1979年 / 64卷 / 01期

关键词：

D O I：

10.1016/0165-1161(79)90131-6

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

More than 200 chemicals, comprising drugs, pesticides, herbicides, industrial chemicals, food additives, etc. tested by various workers for their ability to induce gene conversion in diploid yeast, have been reviewed. This review shows that a strong correlation exists between the convertogenic and mutagenic abilities of these chemicals. This conclusion confirms the earlier one by Zimmermann which was based on fewer mutagenic chemicals. Published data have further been analysed to confirm quantitatively Zimmermann's other important conclusion that gene conversion is not mutagen-specific. This is a positive advantage in using gene conversion in preliminary screening of chemicals because it reduces the chances of false negatives. © 1979.

引用

页码：1 / 17

页数：17

共 61 条

[1] IMPROVED BACTERIAL TEST SYSTEM FOR DETECTION AND CLASSIFICATION OF MUTAGENS AND CARCINOGENS [J].