AUTOANTIBODIES IN MALE-HOMOSEXUALS AND HIV-INFECTION

被引:30
作者
ARGOV, S
SCHATTNER, A
BURSTEIN, R
HANDZEL, ZT
SHOENFELD, Y
BENTWICH, Z
机构
[1] HEBREW UNIV JERUSALEM,KAPLAN HOSP,SCH MED,RUTH BEN ARI INST CLIN IMMUNOL,IL-76100 REHOVOT,ISRAEL
[2] BEN GURION UNIV NEGEV,HLTH SCI CTR,IL-84105 BEER SHEVA,ISRAEL
关键词
AIDS; HIV; HOMOSEXUAL; ANTINUCLEAR ANTIBODY; AUTOANTIBODY; AUTOIMMUNITY;
D O I
10.1016/0165-2478(91)90086-P
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
We have used ELISA to study the frequency of autoantibodies to several antigens in the serum of 17 male homosexuals (MHS) negative for HIV (HIV-), 11 asymptomatic HIV seropositive MHS (HIV+) and patients with ARC (N = 15) or AIDS (N = 13), and compared them to 20 matched healthy heterosexual controls. Serum antibody binding to histones, cardiolipin, ss-A, ss-B and Sm was found to be significantly higher in each of the MHS groups studied as compared to controls (P < 0.001), and was also increased in the HIV+ patients vs. the HIV- group (P < 0.05). In contrast, no increase in autoantibodies to ss-DNA, ds-DNA, poly(I), poly(G) or RNP were found in any of the groups tested. These results enlarge the spectrum of autoimmunity previously reported in HIV infection and identify a similar pattern to a lesser degree, already present in HIV- MHS, suggesting a role for HIV or concomitant virus infections in its pathogenesis.
引用
收藏
页码:31 / 36
页数:6
相关论文
共 33 条
[1]   HOMEOSTASIS OF THE ANTIBODY-RESPONSE - IMMUNOREGULATION BY NK CELLS [J].
ABRUZZO, LV ;
ROWLEY, DA .
SCIENCE, 1983, 222 (4624) :581-585
[2]  
ALGUILAR JL, 1988, AM J MED, V85, P283
[3]  
[Anonymous], 1956, NONPARAMETRIC STAT B
[4]   IMMUNE IMPAIRMENTS AND ANTIBODIES TO HTLVIII/LAV IN ASYMPTOMATIC MALE-HOMOSEXUALS IN ISRAEL - RELEVANCE TO THE RISK OF ACQUIRED-IMMUNE-DEFICIENCY-SYNDROME (AIDS) [J].
BENTWICH, Z ;
SAXINGER, C ;
BENISHAY, Z ;
BURSTEIN, R ;
BERNER, Y ;
PECHT, M ;
TRAININ, N ;
LEVIN, S ;
HANDZEL, ZT .
JOURNAL OF CLINICAL IMMUNOLOGY, 1987, 7 (05) :376-380
[5]  
BENTWICH Z, 1988, LEUKEMIA, V2, pS241
[6]   RHEUMATIC MANIFESTATIONS OF HUMAN IMMUNODEFICIENCY VIRUS-INFECTION [J].
BERMAN, A ;
ESPINOZA, LR ;
DIAZ, JD ;
AGUILAR, JL ;
ROLANDO, T ;
VASEY, FB ;
GERMAIN, BF ;
LOCKEY, RF .
AMERICAN JOURNAL OF MEDICINE, 1988, 85 (01) :59-64
[7]   ANTICARDIOLIPIN ANTIBODIES ASSOCIATED WITH HTLV-III INFECTION [J].
CANOSO, RT ;
ZON, LI ;
GROOPMAN, JE .
BRITISH JOURNAL OF HAEMATOLOGY, 1987, 65 (04) :495-498
[8]   IDENTIFICATION OF HOMOLOGOUS REGIONS IN HUMAN IMMUNODEFICIENCY VIRUS-I GP41 AND HUMAN MHC CLASS-II BETA-1 DOMAIN .1. MONOCLONAL-ANTIBODIES AGAINST THE GP41-DERIVED PEPTIDE AND PATIENTS SERA REACT WITH NATIVE HLA CLASS-II ANTIGENS, SUGGESTING A ROLE FOR AUTOIMMUNITY IN THE PATHOGENESIS OF ACQUIRED IMMUNE-DEFICIENCY SYNDROME4 [J].
GOLDING, H ;
ROBEY, FA ;
GATES, FT ;
LINDER, W ;
BEINING, PR ;
HOFFMAN, T ;
GOLDING, B .
JOURNAL OF EXPERIMENTAL MEDICINE, 1988, 167 (03) :914-923
[9]  
GRANT MD, 1990, J IMMUNOL, V144, P1241
[10]   RHEUMATOLOGIC MANIFESTATIONS OF INFECTION WITH HUMAN IMMUNODEFICIENCY VIRUS (HIV) [J].
KAYE, BR .
ANNALS OF INTERNAL MEDICINE, 1989, 111 (02) :158-167