CHYMOTRYPSIN SUSPENDED IN ORGANIC-SOLVENTS WITH SALT HYDRATES IS A GOOD CATALYST FOR PEPTIDE-SYNTHESIS FROM MAINLY UNDISSOLVED REACTANTS

被引：66

作者：

KUHL, P ^{[1
]}

HALLING, PJ ^{[1
]}

JAKUBKE, HD ^{[1
]}

机构：

[1] UNIV STRATHCLYDE,DEPT BIOSCI & BIOTECHNOL,GLASGOW G1 1XW,SCOTLAND

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 36期

关键词：

D O I：

10.1016/S0040-4039(00)97845-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chymotrypsin powder suspended in organic solvents in the presence of Na2CO3.10H2O catalyses peptide synthesis from X-Ala-Phe-OMe and Leu-NH2 (X = Boc or Z). The reaction proceeds best in the most non-polar solvents, such as hexane, despite the fact that both reactants and products remain largely undissolved. Leu-NH2.HCl can be used in place of the free base. © 1990.

引用

页码：5213 / 5216

页数：4