NK-1 TACHYKININ RECEPTOR IN RAT AND GUINEA-PIG BRAINS - PHARMACOLOGICAL AND AUTORADIOGRAPHICAL EVIDENCE FOR A SPECIES-DIFFERENCE

被引：22

作者：

PETITET, F ^{[1
]}

BEAUJOUAN, JC ^{[1
]}

SAFFROY, M ^{[1
]}

TORRENS, Y ^{[1
]}

FARDIN, V ^{[1
]}

GLOWINSKI, J ^{[1
]}

机构：

[1] RHONE POULENC RORER,CTR RECH VITRY ALFORVILLE,F-94403 VITRY,FRANCE

来源：

PEPTIDES | 1993年 / 14卷 / 03期

关键词：

TACHYKININS; NK-1; RECEPTOR; SPECIES DIFFERENCE; BINDING STUDIES; AUTORADIOGRAPHY;

D O I：

10.1016/0196-9781(93)90144-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The affinities of a large variety of peptide or nonpeptide tachykinin analogues were determined on membranes from rat and guinea pig brains using the selective NK-1 radioligand H-3-[Pro9]SP. Nonpeptide antagonists clearly revealed a species difference; (+/-)CP-96,345 was more potent in the guinea pig, while RP 67580 was found to be a better competitor of H-3-[Pro9]SP binding to rat brain membranes. This was confirmed on brain slices by autoradiography. Numerous brain structures were analyzed by optical densitometry. From these data, a heterogeneity of NK-1 binding sites among different structures can be excluded in both rat and guinea pig brains.

引用

页码：551 / 559

页数：9

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