DISPIROKETALS IN SYNTHESIS .6. HIGHLY STEREOSELECTIVE ALKYLATION OF DISPIROKETAL PROTECTED LACTATE AND GLYCOLATE ENOLATES

被引：24

作者：

DOWNHAM, R ^{[1
]}

KIM, KS ^{[1
]}

LEY, SV ^{[1
]}

WOODS, M ^{[1
]}

机构：

[1] UNIV CAMBRIDGE,DEPT CHEM,CAMBRIDGE CB2 1EW,ENGLAND

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 05期

关键词：

D O I：

10.1016/S0040-4039(00)75813-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Protected lactic acid enolates have been alkylated with a range of electrophiles to give the substituted adducts with moderate to excellent stereoselectivity. A chiral protected glycolic acid adduct has also been doubly alkylated with high stereoselectivity.

引用

页码：769 / 772

页数：4

共 9 条

[1]

BOONS GJ, 1993, TETRAHEDRON LETT, V34, P5649

[2]

BOONS GJ, 1990, SYNTHESIS-STUTTGART, P689

[3] ACYCLIC STEREOSELECTION .4. ASSIGNMENT OF STEREOSTRUCTURE TO BETA-HYDROXYCARBONYL COMPOUNDS BY C-13 NUCLEAR MAGNETIC-RESONANCE [J].