ANTINOCICEPTION INDUCED BY 3-((PLUS-OR-MINUS)-2-CARBOXYPIPERAZIN-4-YL)-PROPYL-1-PHOSPHONIC ACID (CPP), AN N-METHYL-D-ASPARTATE (NMDA) COMPETITIVE ANTAGONIST, PLUS 6,7-DINITROQUINOXALINE-2,3-DIONE (DNQX), A NON-NMDA ANTAGONIST, DIFFERS FROM THAT INDUCED BY MK-801 PLUS DNQX

被引：11

作者：

GOETTL, VM ^{[1
]}

LARSON, AA ^{[1
]}

机构：

[1] UNIV MINNESOTA,DEPT VET PATHOBIOL,GRAD PROGRAM NEUROSCI,ST PAUL,MN 55108

来源：

BRAIN RESEARCH | 1994年 / 642卷 / 1-2期

关键词：

N-METHYL-D-ASPARTATE; NON-N-METHYL-D-ASPARTATE; FORMALIN; PAIN; PCP; 6,7-DINITROQUINOXALINE-2,3-DIONE; 3-((PLUS-OR-MINUS)-2-CARBOXYPIPERAZIN-4-YL)-PROPYL-1-PHOSPHONIC ACID; MK-801;

D O I：

10.1016/0006-8993(94)90939-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Excitatory amino acid receptors have been implicated in mediating pain. 3-((+/-)-2-Carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP), a competitive N-methyl-D-aspartate (NMDA) antagonist and MK-801, a phencyclidine (PCP) ligand and non-competitive NMDA antagonist, were injected intrathecally in mice alone or in combination with 6,7-dinitroquinoxaline-2,3-dione (DNQX), a non-NMDA antagonist. When tested in the formalin model of pain, antinociception following CPP plus DNQX was greater than that after MK-801 plus DNQX in both the acute and tonic phases. These dissimilarities are not consistent with activity of CPP and MK-801 at the same sites in the spinal cord.

引用

页码：334 / 338

页数：5

共 21 条

[1] PHENCYCLIDINE AND SIGMA-RECEPTORS IN RAT SPINAL-CORD - BINDING CHARACTERIZATION AND QUANTITATIVE AUTORADIOGRAPHY [J].

AANONSEN, LM ;

SEYBOLD, VS .

SYNAPSE, 1989, 4 (01) :1-10

[2] THE BEHAVIORAL-EFFECTS OF AN N-METHYLASPARTATE RECEPTOR ANTAGONIST FOLLOWING APPLICATION TO THE LUMBAR SPINAL-CORD OF CONSCIOUS RATS [J].

CAHUSAC, PMB ;

EVANS, RH ;

HILL, RG ;

RODRIQUEZ, RE ;

SMITH, DAS .

NEUROPHARMACOLOGY, 1984, 23 (7A) :719-724

[3] CENTRAL-NERVOUS-SYSTEM PLASTICITY IN THE TONIC PAIN RESPONSE TO SUBCUTANEOUS FORMALIN INJECTION [J].

CODERRE, TJ ;

VACCARINO, AL ;

MELZACK, R .

BRAIN RESEARCH, 1990, 535 (01) :155-158

[4]

CODERRE TJ, 1992, J NEUROSCI, V12, P3365

[5] DIFFERENTIAL-EFFECTS OF EXCITATORY AMINO-ACID ANTAGONISTS ON DORSAL HORN NOCICEPTIVE NEURONS IN THE RAT [J].

DICKENSON, AH ;

SULLIVAN, AF .

BRAIN RESEARCH, 1990, 506 (01) :31-39

[6] THE ROLE OF NMDA AND NON-NMDA EXCITATORY AMINO-ACID RECEPTORS IN THE EXCITATION OF PRIMATE SPINOTHALAMIC TRACT NEURONS BY MECHANICAL, CHEMICAL, THERMAL, AND ELECTRICAL STIMULI [J].

DOUGHERTY, PM ;

PALECEK, J ;

PALECKOVA, V ;

SORKIN, LS ;

WILLIS, WD .

JOURNAL OF NEUROSCIENCE, 1992, 12 (08) :3025-3041

[7]

Goettl V. M., 1993, Society for Neuroscience Abstracts, V19, P967

[8] EVIDENCE FOR SPINAL N-METHYL-D-ASPARTATE RECEPTOR INVOLVEMENT IN PROLONGED CHEMICAL NOCICEPTION IN THE RAT [J].

HALEY, JE ;

SULLIVAN, AF ;

DICKENSON, AH .

BRAIN RESEARCH, 1990, 518 (1-2) :218-226

[9] BINDING-STUDIES AND PHOTOAFFINITY-LABELING IDENTIFY 2 CLASSES OF PHENCYCLIDINE RECEPTORS IN RAT-BRAIN [J].

HARING, R ;

KLOOG, Y ;

KALIR, A ;

SOKOLOVSKY, M .

BIOCHEMISTRY, 1987, 26 (18) :5854-5861

[10] QUINOXALINEDIONES - POTENT COMPETITIVE NON-NMDA GLUTAMATE RECEPTOR ANTAGONISTS [J].

HONORE, T ;

DAVIES, SN ;

DREJER, J ;

FLETCHER, EJ ;

JACOBSEN, P ;

LODGE, D ;

NIELSEN, FE .

SCIENCE, 1988, 241 (4866) :701-703

← 1 2 3 →