N-OMEGA-NITRO-L-ARGININE METHYL-ESTER REDUCES THE INCIDENCE OF IDDM IN BB/E RATS

被引:55
作者
LINDSAY, RM [1 ]
SMITH, W [1 ]
ROSSITER, SP [1 ]
MCINTYRE, MA [1 ]
WILLIAMS, BC [1 ]
BAIRD, JD [1 ]
机构
[1] UNIV EDINBURGH,WESTERN GEN HOSP,DEPT PATHOL,EDINBURGH EH4 2XU,MIDLOTHIAN,SCOTLAND
关键词
D O I
10.2337/diabetes.44.3.365
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Evidence that nitric oxide (NO) is involved in cytokine-mediated islet beta-cell dysfunction and destruction in vitro has led to the hypothesis that increased production of NO may contribute to the pathogenesis of insulin-dependent diabetes mellitus (IDDM), This study demonstrates that oral administration of N-omega-nitro-L-arginine methyl ester (an inhibitor of NO synthase) from 30 to 150 days of age significantly reduced (P < 0.05) the incidence of IDDM in diabetes-prone BB/E rats. This supports the idea that NO plays a significant role in the pathogenesis of IDDM in this animal model.
引用
收藏
页码:365 / 368
页数:4
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