CCKB RECEPTOR ACTIVATION PROTECTS CA1 NEURONS FROM ISCHEMIA-INDUCED DYSFUNCTION IN STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RATS HIPPOCAMPAL SLICES

被引：11

作者：

YASUI, M ^{[1
]}

KAWASAKI, K ^{[1
]}

机构：

[1] SHIONOGI & CO LTD, DIV PHARMACOL, DEV RES LABS, TOYONAKA, OSAKA 561, JAPAN

来源：

NEUROSCIENCE LETTERS | 1995年 / 191卷 / 1-2期

关键词：

CHOLECYSTOKININ OCTAPEPTIDE (CCK-8); ISCHEMIC DAMAGE; CA1 PYRAMIDAL NEURON; HIPPOCAMPAL SLICE; STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RATS (SHRSP);

D O I：

10.1016/0304-3940(95)11570-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We examined the effect of cholecystokinin octapeptide sulfated type (CCK-8S) on dysfunction of CA1 pyramidal neurons induced by in vitro ischemic insult in hippocampal slices of stroke-prone spontaneously hypertensive rats (SHRSP). CCK-8S shortened the time required for partial recovery from block of a population spike produced by ischemia. Furthermore. CCK-8S reduced ischemic insult-induced accumulation of K+ in extracellular space. Suppression of the K+ conductance by the CCKB receptor activation is suggested to contribute to neuroprotection by CCK-8S.

引用

页码：99 / 102

页数：4

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