EFFECTS OF THEOPHYLLINE ON SALICYLATE TRANSPORT IN ISOLATED RAT JEJUNUM

被引：18

作者：

BARNETT, G ^{[1
]}

HUI, S ^{[1
]}

BENET, LZ ^{[1
]}

机构：

[1] UNIV CALIF SAN FRANCISCO,SCH PHARM,SAN FRANCISCO,CA 94143

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1978年 / 507卷 / 03期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0005-2736(78)90359-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Salicyclic acid flux at pH 7.4 across rat jejunum was measured before and after perturbation with theophylline and/or an electric field. After the flux reached a steady state control condition theophylline was added to the system, which resulted in establishment of a new higher steady state flux. Dependence of flux on an externally applied potential difference was observed to have a strong exponential behavior. It appears that salicylate transport is primarily via the shunt pathway and the effect of theophylline is to increase transport by the low resistance pathway. © 1978.

引用

页码：517 / 523

页数：7

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