ALTERED REGULATION OF PANCREATIC GLUCAGON IN MALE-RATS DURING AGING

被引：10

作者：

KLUG, TL

FREEMAN, C

KAROLY, K

ADELMAN, RC

机构：

[1] TEMPLE UNIV,INST AGING,PHILADELPHIA,PA 19140

[2] PHILADELPHIA GERIATR CTR,DIV BIOMED RES,PHILADELPHIA,PA 19141

[3] FELS RES INST STUDY HUMAN DEV,YELLOW SPRINGS,OH 45387

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 89卷 / 03期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0006-291X(79)91864-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Immunoreactive pancreatic glucagon levels in portal vein blood following intragastric glucose administration were determined in fasted male Sprague-Dawley rats of 2-, 12-, and 24-months of age. Immunoreactive glucagon levels decline to less than one-half the fasting values in 2-month old rats following glucose administration, whereas immunoreactive glucagon levels increase two to three times the fasting values in 12- and 24-month old rats under the same conditions. Glucagon inhibits glucose-stimulated hepatic glucokinase adaptation and may interfere with insulin action in the regulation of hepatic glucose balance. Therefore, differences in the availability of glucagon may contribute significantly to delayed hepatic glucokinase adaptation in rats during aging. © 1979.

引用

页码：907 / 912

页数：6

共 19 条

[1] PANCREATIC GLUCAGON SECRETION IN NORMAL AND DIABETIC SUBJECTS [J].