IN VITRO DEMONSTRATION OF TUMOR-SPECIFIC ANTIGENS IN SPONTANEOUS MAMMARY TUMORS OF MICE

被引：76

作者：

HEPPNER, GH

PIERCE, G

机构：

[1] Department of Pathology, Department of Surgery, University of Washington School of Medicine, Seattle, Washington

来源：

INTERNATIONAL JOURNAL OF CANCER | 1969年 / 4卷 / 02期

关键词：

D O I：

10.1002/ijc.2910040211

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The colony‐inhibition test has been used to demonstrate cellular immunity against spontaneous murine mammary tumors, both in autochthonous, mammary tumor virus (MTV)‐carrying BALB/cfC3H and in immunized, MTV‐free, BALB/c mice. Immunity could be demonstrated in nearly all cases against a mammary tumor with lymph‐node cells from mice which had experienced that tumor. One of eight tumors tested with lymph‐node cells from BALB/cfC3H mice which had spontaneously developed mammary tumors showed evidence of immunological cross‐reactivity, while seven of thirteen tumors did so when tested with immune cells from MTV‐free BALB/c mice. The data, therefore, indicate the presence of at least two types of tumor‐specific antigen (s) in mouse mammary tumors — a common one and an antigen specific for each neoplasm. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company

引用

页码：212 / &

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