COLCHICINE MODELS - SYNTHESIS AND ANTITUBULIN ACTIVITY OF 2'-MONOSUBSTITUTED AND 2',5-DISUBSTITUTED 2,3,4,4'-TETRAMETHOXY-1,1'-BIPHENYLS - SYNTHESIS OF 4,4',5',6'-TETRAMETHOXY-1,1'-BIPHENYL-2,3'-DICARBOXYLIC ACID

被引：13

作者：

ITOH, Y

BROSSI, A

HAMEL, E

FLIPPENANDERSON, JL

GEORGE, C

机构：

[1] NIDDK,ANALYT CHEM LAB,MED CHEM SECT,BETHESDA,MD 20892

[2] NCI,BIOCHEM PHARMACOL LAB,BETHESDA,MD 20892

[3] USN,RES LAB,STRUCT MATTER LAB,WASHINGTON,DC 20375

[4] NCI,DIV CANC TREATMENT,DEV THERAPEUT PROGRAM,BETHESDA,MD 20892

来源：

HELVETICA CHIMICA ACTA | 1989年 / 72卷 / 02期

关键词：

D O I：

10.1002/hlca.19890720203

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

引用

页码：196 / 204

页数：9

共 12 条

[1] SYNTHESIS, X-RAY CRYSTAL-STRUCTURE, AND ANTIMITOTIC PROPERTIES OF 6-CHLORO-2-METHOXY-5-(2',3',4'-TRIMETHOXYPHENYL)CYCLOHEPTA-2,4,6-TRIEN-1-ONE, A BICYCLIC ANALOG OF COLCHICINE [J].

BANWELL, MG ;

HERBERT, KA ;

BUCKLETON, JR ;

CLARK, GR ;

RICKARD, CEF ;

LIN, CM ;

HAMEL, E .

JOURNAL OF ORGANIC CHEMISTRY, 1988, 53 (21) :4945-4952

[2] METHYLENEDIOXY-BENZOPYRAN ANALOGS OF PODOPHYLLOTOXIN, A NEW SYNTHETIC CLASS OF ANTIMITOTIC AGENTS THAT INHIBIT TUBULIN POLYMERIZATION [J].

BATRA, JK ;

KANG, GJ ;

JURD, L ;

HAMEL, E .

BIOCHEMICAL PHARMACOLOGY, 1988, 37 (13) :2595-2602

[3] COLCHICINE AND ITS ANALOGS - RECENT FINDINGS [J].

BROSSI, A ;

YEH, HJC ;

CHRZANOWSKA, M ;

WOLFF, J ;

HAMEL, E ;

LIN, CM ;

QUIN, F ;

SUFFNESS, M ;

SILVERTON, J .

MEDICINAL RESEARCH REVIEWS, 1988, 8 (01) :77-94

[4]

FITZGERALD TJ, 1976, BIOCHEM PHARMACOL, V25, P1383

[5]

IORIO MA, 1984, HETEROCYCLES, V22, P2207

[6] COLCHICINE MODELS - SYNTHESIS AND BINDING TO TUBULIN OF TETRAMETHOXYBIPHENYLS [J].

ITOH, Y ;

BROSSI, A ;

HAMEL, E ;

LIN, CM .

HELVETICA CHIMICA ACTA, 1988, 71 (05) :1199-1209

[7]

LIPSKY SD, 1988, ORG SYNTH COLL, V6, P537

[8]

RAVID M, 1988, IN PRESS AMYLOIDOSIS

[9]

SHELDRICK G, 1980, SHELXTL MINICOMPUTER

[10]

WILDMAN W. C., 1960, ALKALOIDS, V6, P247

← 1 2 →