ASYMMETRIC-SYNTHESIS OF L-DIPHENYLALANINE AND L-9-FLUORENYLGLYCINE VIA ROOM-TEMPERATURE ALKYLATIONS OF A SULTAM-DERIVED GLYCINE IMINE

被引：74

作者：

JOSIEN, H ^{[1
]}

MARTIN, A ^{[1
]}

CHASSAING, G ^{[1
]}

机构：

[1] UNIV PARIS 06,CHIM ORGAN BIOL LAB,CNRS,UA 493,PARIS,FRANCE

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 45期

关键词：

L-DIPHENYLALANINE; L-9-FLUORENYLGLYCINE; SULTAM-DERIVED GLYCINE IMINE; ASYMMETRIC ROOM TEMPERATURE ALKYLATION; MILD SULTAM DEPROTECTION;

D O I：

10.1016/0040-4039(91)80217-T

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

L-diphenylalanine and L-9-fluorenylglycine were prepared from a sultam-derivated glycine imine 3 via room temperature-asymmetric-alkylation/ hydrolysis/mild-sultam-clivage. The L-configuration was ascertained using an X-ray analysis of the alkylation product 4b.

引用

页码：6547 / 6550

页数：4

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