POSSIBLE ROLE OF TYROSINE KINASES IN THE PROLACTIN STIMULATION OF CELL-DIVISION IN NB2 NODE LYMPHOMA-CELLS

被引：7

作者：

FAN, G ^{[1
]}

CARBAJO, P ^{[1
]}

RILLEMA, JA ^{[1
]}

机构：

[1] WAYNE STATE UNIV,SCH MED,SCH MED,DEPT PHYSIOL,540 E CANFIELD,DETROIT,MI 48201

来源：

HORMONE AND METABOLIC RESEARCH | 1993年 / 25卷 / 05期

关键词：

GENISTEIN; ORTHOVANADATE; NB2 NODE LYMPHOMA CELLS; TYROSINE KINASE; TYROSINE PHOSPHATASE; PROLACTIN;

D O I：

10.1055/s-2007-1002091

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Orthovanadate and genistein were employed to determine the possible role of tyrosine kinase in the prolactin stimulation of cell division in Nb2 node lymphoma cells. Orthovanadate (0.1-0.25 muM), an inhibitor of specific phosphatases, was found to stimulate cell division as well as potentiate the mitogenic effect of prolactin on Nb2 cells when prolactin was employed at a less than maximum stimulatory concentration. Genistein, an inhibitor of tyrosine kinase, was found to inhibit the prolactin stimulation of cell division. Since prolactin was shown in earlier studies to stimulate the phosphorylation of tyrosyl residues in specific Nb2 cell proteins, these results suggest that the signal transduction pathway for the prolactin stimulation of cell division in the Nb2 node lymphoma cells likely involves the participation of tyrosine kinase(s).

引用

页码：256 / 258

页数：3

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