IN-VITRO DRUG-RELEASE FROM CHITOSAN MEMBRANES - STUDY OF THE MECHANISMS OF PERMEATION

被引：6

作者：

BONVIN, MM ^{[1
]}

DEBERTORELLO, MM ^{[1
]}

机构：

[1] UNIV NACL CORDOBA,FAC CIENCIAS QUIM,DEPT FARM,RA-5016 CORDOBA,ARGENTINA

来源：

POLYMER BULLETIN | 1994年 / 32卷 / 01期

关键词：

D O I：

10.1007/BF00297416

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

In vitro studies of controlled release from chitosan membranes were carried out using drugs of different molecular weight. The release rate was measured in water at 37 degrees +/- 0.5 degrees C by determining the amount of drug released by spect rophotometric analysis. It was found that release of acetamide, nicotinamide, sodium benzoate, sodium salicylate, phenobarbital sodium and sodium cefazoline followed zero-order kinetics. The relation between molecular weight and diffusion coefficient was established.

引用

页码：69 / 75

页数：7

共 9 条

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