ESTROGEN-RECEPTOR ASSAY OF BREAST-CANCER BY IMMUNOCYTOCHEMISTRY OF FINE NEEDLE ASPIRATES

被引：5

作者：

KITCHEN, PRB

STILLWELL, RG

HENDERSON, MA

BENNETT, RC

RENNIE, GC

KOU, SJ

GEORGIOU, T

AYBERK, H

机构：

[1] Departments of Surgery, St Vincent's Hospital, Fitzroy, Victoria

[2] Departments of Anatomical Pathology, St Vincent's Hospital, Fitzroy, Victoria

来源：

AUSTRALIAN AND NEW ZEALAND JOURNAL OF SURGERY | 1991年 / 61卷 / 03期

关键词：

BREAST NEOPLASMS; IMMUNOCYTOCHEMISTRY; MONOCLONAL ANTIBODY; ESTROGEN RECEPTOR;

D O I：

10.1111/j.1445-2197.1991.tb07596.x

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Sixty-five patients with operable breast cancer were studied to assess the reliability of immunocytochemical analysis of oestrogen receptor (ER-ICA) in specimens obtained by percutaneous fine needle aspiration. Results obtained with the commercially available ER-ICA kit were compared with those obtained by the routine biochemical radioligand assay of oestrogen receptor (ER) on excised tumour specimens. Fifty-two of 65 percutaneous aspirates were evaluable. Of these, thirty-five (67%) were ER positive by the radioligand method. ER-ICA was found to be a reliable method for oestrogen recepter assay, with a high concordance (90.4%) between it and the radioligand essay. The ER-ICA assay had a sensitivity of 89%, specificity of 94%, positive predictive value of 97% and negative predictive value of 80%. ER-ICA assay performed on material obtained by fine-needle aspiration is a reliable method of ER assay. It can replace formal biopsy for patients with inoperable primary tumours or accessible metastases.

引用

页码：223 / 228

页数：6

共 25 条

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