CIRCULATING ESTROGENS IN A MALE SONGBIRD ORIGINATE IN THE BRAIN

被引:141
作者
SCHLINGER, BA [1 ]
ARNOLD, AP [1 ]
机构
[1] UNIV CALIF LOS ANGELES,BRAIN RES INST,NEUROENDOCRINOL LAB,LOS ANGELES,CA 90024
关键词
AROMATASE; TELENCEPHALON; ZEBRA FINCH; GONADS; ADRENALS;
D O I
10.1073/pnas.89.16.7650
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Gonadal steroids act on brain to regulate the development and expression of vertebrate reproductive behavior. In addition, steroid targets in brain are an integral part of the feedback regulation of gonadal steroidogenesis. The actions of androgens in brain are often mediated by enzymatic activation or inactivation of circulating hormone, including local conversion of androgen to estrogen. We now report that in zebra finches, the brain synthesizes large quantities of estrogen from androgen and releases this estrogen into blood. Since there appears to be no other significant source of estrogen synthesis in adult male zebra finches, it is likely that the brain directly controls plasma levels of this steroid by contributing most or all of the high levels of estrogen found in the circulation.
引用
收藏
页码:7650 / 7653
页数:4
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