PARALLEL ALTERATIONS IN MET-ENKEPHALIN AND SUBSTANCE-P LEVELS IN MEDIAL GLOBUS-PALLIDUS IN PARKINSONS-DISEASE PATIENTS

被引:15
作者
DECEBALLOS, ML
FERNANDEZ, A
JENNER, P
MARSDEN, CD
机构
[1] KINGS COLL LONDON,DIV BIOMED SCI,PHARMACOL GRP,PARKINSONS DIS SOC EXPTL RES LABS,MANRESA RD,LONDON SW3 6LX,ENGLAND
[2] CSIC,CAJAL INST,DEPT NEUROPHARMACOL,MADRID 6,SPAIN
[3] NATL HOSP,INST NEUROL,DEPT CLIN NEUROL,LONDON WC1N 3BG,ENGLAND
基金
英国医学研究理事会;
关键词
MET-ENKEPHALIN; SUBSTANCE-P; BASAL GANGLION; PARKINSONS DISEASE;
D O I
10.1016/0304-3940(93)90404-9
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Met-enkephalin (Met-enk) and substance P (SP) were measured by a combined high-performance liquid chromatography/radioimmunoanalysis method in medial (GPM) and lateral globus pallidus (GPL) from controls and from Parkinson's disease (PD) patients. All patients showed a similar marked (> 90%) reduction in dopamine (DA) levels in putamen compared with controls. However, based on DA levels in the caudate nucleus, two subgroups of PD patients were differentiated. In patients with > 80% decrease in caudate nucleus DA content, there was a three-fold increase in both Met-enk and SP levels in GPM. In contrast, in patients showing an approximately 50% reduction in DA content in caudate, levels of both peptides were markedly reduced (approximately 80%). Met-enk and SP levels in GPL were unchanged in PD. These results suggest that neurons containing Met-enk and SP projecting to GPM adapt according to the extent of degeneration in the substantia nigra in PD.
引用
收藏
页码:163 / 166
页数:4
相关论文
共 17 条
[1]  
AGID Y, 1985, TRENDS NEUROSCI, V7, P30
[2]   MET-ENKEPHALIN IMMUNOREACTIVITY IN THE BASAL GANGLIA IN SYMPTOMATIC AND ASYMPTOMATIC MPTP-EXPOSED MONKEYS - CORRELATION WITH DEGREE OF PARKINSONIAN SYMPTOMS [J].
DACKO, S ;
SCHNEIDER, JS .
NEUROSCIENCE LETTERS, 1991, 127 (01) :49-52
[3]   ISOCRATIC REVERSE-PHASE HPLC SEPARATION AND RIA USED IN THE ANALYSIS OF NEUROPEPTIDES IN BRAIN-TISSUE [J].
DECEBALLOS, ML ;
TAYLOR, MD ;
JENNER, P .
NEUROPEPTIDES, 1991, 20 (03) :201-209
[4]   LEVODOPA REPLACEMENT THERAPY ALTERS ENZYME-ACTIVITIES IN STRIATUM AND NEUROPEPTIDE CONTENT IN STRIATAL OUTPUT REGIONS OF 6-HYDROXYDOPAMINE LESIONED RATS [J].
ENGBER, TM ;
SUSEL, Z ;
KUO, S ;
GERFEN, CR ;
CHASE, TN .
BRAIN RESEARCH, 1991, 552 (01) :113-118
[5]   STRIATAL NEUROPEPTIDE LEVELS IN PARKINSONS-DISEASE PATIENTS [J].
FERNANDEZ, A ;
DECEBALLOS, ML ;
JENNER, P ;
MARSDEN, CD .
NEUROSCIENCE LETTERS, 1992, 145 (02) :171-174
[6]   MET-ENKEPHALIN IMMUNOREACTIVITY IN THE BASAL GANGLIA IN PARKINSONS-DISEASE AND STRIATONIGRAL DEGENERATION [J].
GOTO, S ;
HIRANO, A ;
MATSUMOTO, S .
NEUROLOGY, 1990, 40 (07) :1051-1056
[7]   IMMUNOHISTOCHEMICAL VISUALIZATION OF AFFERENT NERVE-TERMINALS IN HUMAN GLOBUS PALLIDUS AND ITS ALTERATION IN NEOSTRIATAL NEURODEGENERATIVE DISORDERS [J].
GOTO, S ;
HIRANO, A ;
ROJASCORONA, RR .
ACTA NEUROPATHOLOGICA, 1989, 78 (05) :543-550
[8]   IMMUNOCYTOCHEMICAL STUDIES OF SUBSTANCE-P AND MET-ENKEPHALIN IN THE BASAL GANGLIA AND SUBSTANTIA NIGRA IN HUNTINGTONS, PARKINSONS AND ALZHEIMERS DISEASES [J].
GRAFE, MR ;
FORNO, LS ;
ENG, LF .
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1985, 44 (01) :47-59
[9]  
LINDEFORS N, 1989, EXP BRAIN RES, V74, P527
[10]   DECREASE OF SUBSTANCE-P-LIKE IMMUNOREACTIVITY IN THE SUBSTANTIA NIGRA AND PALLIDUM OF PARKINSONIAN BRAINS [J].
MAUBORGNE, A ;
JAVOYAGID, F ;
LEGRAND, JC ;
AGID, Y ;
CESSELIN, F .
BRAIN RESEARCH, 1983, 268 (01) :167-170