SPERMINE DEPRESSES NMDA, K/AMPA AND GABA(A)-MEDIATED SYNAPTIC TRANSMISSION IN THE RAT HIPPOCAMPAL SLICE PREPARATION

被引：19

作者：

DISCENNA, PG ^{[1
]}

FERCHMIN, PA ^{[1
]}

ETEROVIC, VA ^{[1
]}

TEYLER, TJ ^{[1
]}

机构：

[1] UNIV CENT CARIBE,COLL MED,DEPT BIOCHEM,BAYAMON,PR 00960

来源：

BRAIN RESEARCH | 1994年 / 647卷 / 02期

关键词：

CAI; HIPPOCAMPUS; N-METHYL-D-ASPARTATE; POLYAMINE; SPERMINE;

D O I：

10.1016/0006-8993(94)91335-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of spermine, an endogenous polyamine, were examined in area CA1 of the rat hippocampal slice preparation. Spermine, at low millimolar concentrations, rapidly and potently depressed NMDA and K/AMPA-mediated population EPSPs, and GABA-mediated monosynaptic population IPSPs. These effects contrast with its well-known potentiation of NMDA currents at lower concentrations. Our results raise the possibility that the large intracellular stores of spermine that are released after various neural insults could act as an endogenous neuroprotective mechanism by:limiting excessive calcium entry.

引用

页码：353 / 356

页数：4

共 28 条

[1] EFFECTS OF POLYAMINES ON NMDA-INDUCED CURRENTS IN RAT HIPPOCAMPAL-NEURONS - A WHOLE-CELL AND SINGLE-CHANNEL STUDY [J].

ARANEDA, RC ;

ZUKIN, RS ;

BENNETT, MVL .

NEUROSCIENCE LETTERS, 1993, 152 (1-2) :107-112

[2] MULTIPLE EFFECTS OF SPERMINE ON N-METHYL-D-ASPARTIC ACID RECEPTOR RESPONSES OF RAT CULTURED HIPPOCAMPAL-NEURONS [J].

BENVENISTE, M ;

MAYER, ML .

JOURNAL OF PHYSIOLOGY-LONDON, 1993, 464 :131-163

[3] SPERMINE AND PHILANTHOTOXIN POTENTIATE EXCITATORY AMINO-ACID RESPONSES OF XENOPUS OOCYTES INJECTED WITH RAT AND CHICK BRAIN-RNA [J].

BRACKLEY, P ;

GOODNOW, R ;

NAKANISHI, K ;

SUDAN, HL ;

USHERWOOD, PNR .

NEUROSCIENCE LETTERS, 1990, 114 (01) :51-56

[4] QUISQUALATE-SENSITIVE GLUTAMATE RECEPTORS OF THE LOCUST SCHISTOCERCA-GREGARIA ARE ANTAGONIZED BY INTRACELLULARLY APPLIED PHILANTHOTOXIN AND SPERMINE [J].

BRUNDELL, P ;

GOODNOW, R ;

KERRY, CJ ;

NAKANISHI, K ;

SUDAN, HL ;

USHERWOOD, PNR .

NEUROSCIENCE LETTERS, 1991, 131 (02) :196-200

[5] PAIRED-PULSE DEPRESSION OF MONOSYNAPTIC GABA-MEDIATED INHIBITORY POSTSYNAPTIC RESPONSES IN RAT HIPPOCAMPUS [J].

DAVIES, CH ;

DAVIES, SN ;

COLLINGRIDGE, GL .

JOURNAL OF PHYSIOLOGY-LONDON, 1990, 424 :513-531

[6]

DEVERA N, 1991, J NEUROCHEM, V57, P1

[7] OMEGA-CONOTOXIN GVIA BLOCKS SYNAPTIC TRANSMISSION IN THE CA1 FIELD OF THE HIPPOCAMPUS [J].

DUTAR, P ;

RASCOL, O ;

LAMOUR, Y .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1989, 174 (2-3) :261-266

[8] SELECTIVE RELEASE OF SPERMINE AND SPERMIDINE FROM THE RAT STRIATUM BY N-METHYL-D-ASPARTATE RECEPTOR ACTIVATION INVIVO [J].

FAGE, D ;

VOLTZ, C ;

SCATTON, B ;

CARTER, C .

JOURNAL OF NEUROCHEMISTRY, 1992, 58 (06) :2170-2175

[9] HYPERPOLARIZING AND DEPOLARIZING GABA-A RECEPTOR-MEDIATED DENDRITIC INHIBITION IN AREA CA1 OF THE RAT HIPPOCAMPUS [J].

LAMBERT, NA ;

BORRONI, AM ;

GROVER, LM ;

TEYLER, TJ .

JOURNAL OF NEUROPHYSIOLOGY, 1991, 66 (05) :1538-1548

[10] CHANGES IN REGIONAL POLYAMINE PROFILES IN RAT BRAINS AFTER TRANSIENT CEREBRAL-ISCHEMIA (SINGLE VERSUS REPETITIVE ISCHEMIA) - EVIDENCE FOR RELEASE OF POLYAMINES FROM INJURED NEURONS [J].

PASCHEN, W ;

WIDMANN, R ;

WEBER, C .

NEUROSCIENCE LETTERS, 1992, 135 (01) :121-124

← 1 2 3 →