EFFECTS OF METABOTROPIC GLUTAMATE-RECEPTOR ACTIVATION ON THE CELLULAR AND NETWORK LEVEL IN THE LAMPREY SPINAL-CORD

被引：14

作者：

KRIEGER, P ^{[1
]}

TEGNER, J ^{[1
]}

ELMANIRA, A ^{[1
]}

GRILLNER, S ^{[1
]}

机构：

[1] KAROLINSKA INST,NOBEL INST NEUROPHYSIOL,DEPT NEUROSCI,S-17177 STOCKHOLM,SWEDEN

来源：

NEUROREPORT | 1994年 / 5卷 / 14期

关键词：

LAMPREY; METABOTROPIC GLUTAMATE RECEPTORS; LOCOMOTION; SPINAL CORD; NETWORK;

D O I：

10.1097/00001756-199409080-00018

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THE effects of the metabotropic glutamate receptor (mGluR) agonist ACPD ((1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid) on single neurones and on the network underlying locomotion in the lamprey have been analysed. ACPD induces a depolarization in lamprey spinal cord neurones, which is insensitive to tetrodotoxin (TTX) and ionotropic glutamate receptor antagonists, but is reversibly blocked by the mGluR antagonist MCPG ((+)-alpha-methyl-4-carboxyphenylglycine). The ACPD-induced depolarization persists in a calcium-free solution or when the calcium channel blocker cadmium is added to the solution. At the network level ACPD causes an increased burst frequency during fictive locomotion by increasing the excitability level of network neurones.

引用

页码：1760 / 1762

页数：3

共 25 条

[1] CNQX AND DNQX BLOCK NON-NMDA SYNAPTIC TRANSMISSION BUT NOT NMDA-EVOKED LOCOMOTION IN LAMPREY SPINAL-CORD [J].