A NEW REAGENT FOR THE CLEAVAGE OF FULLY PROTECTED PEPTIDES SYNTHESIZED ON 2-CHLOROTRITYL CHLORIDE RESIN

被引：134

作者：

BOLLHAGEN, R

SCHMIEDBERGER, M

BARLOS, K

GRELL, E

机构：

[1] MAX PLANCK INST BIOPHYS,W-6000 FRANKFURT,GERMANY

[2] UNIV PATRAS,DEPT CHEM,PATRAI,GREECE

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1994年 / 22期

关键词：

D O I：

10.1039/c39940002559

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A mixture of hexafluoroisopropanol-dichloromethane (1 : 4 v/v) acts as a fast, effective and convenient reagent for cleaving protected peptide fragments with a minimal amount of racemization from 2-chlorotrityl chloride resin.

引用

页码：2559 / 2560

页数：2

共 4 条

[1] ESTERIFICATION OF PARTIALLY PROTECTED PEPTIDE-FRAGMENTS WITH RESINS - UTILIZATION OF 2-CHLOROTRITYLCHLORIDE FOR SYNTHESIS OF LEU-15-GASTRIN-I
BARLOS, K
GATOS, D
KAPOLOS, S
PAPAPHOTIU, G
SCHAFER, W
YAO, WQ
[J]. TETRAHEDRON LETTERS, 1989, 30 (30) : 3947 - 3950
[2] BARLOS K, 1991, INT J PEPT PROT RES, V37, P513
[3] SYNTHESIS OF PROTECTED PEPTIDE-FRAGMENTS USING SUBSTITUTED TRIPHENYLMETHYL RESINS
BARLOS, K
GATOS, D
KALLITSIS, J
PAPAPHOTIU, G
SOTIRIU, P
YAO, WQ
SCHAFER, W
[J]. TETRAHEDRON LETTERS, 1989, 30 (30) : 3943 - 3946
[4] BARLOS K, 1991, ANGEW CHEM, V103, P572

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