SYNTHESIS OF 3-HYDROXY-3-PHENACYLOXINDOLE ANALOGS

被引：45

作者：

POPP, FD

DONIGAN, BE

机构：

[1] Department of Chemistry, University of Missouri-Kansas City, Kansas City, Missouri

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1979年 / 68卷 / 04期

基金：

美国国家卫生研究院;

关键词：

3‐Hydroxy‐3‐phenacyloxindole analogs—synthesized as potential anticonvulsants; Acetophenones; substituted— condensed with substituted isatins to give 3‐hydroxy‐3‐phenacyloxindole analogs; screened for anticonvulsant activity; Anticonvulsant activity—screening of 3‐hydroxy‐3‐phenacyloxindole analogs; Isatins; substituted—condensed with substituted acetophenones to give 3‐hydroxy‐3‐phenacyloxindole analogs;

D O I：

10.1002/jps.2600680437

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Substituted isatins and substituted acetophenones were condensed to give analogs of 3‐hydroxy‐3‐phenacyloxindole. These alcohols were dehydrated, and the alkene was reduced. None of the products had the level of anticonvulsant activity exhibited by the parent compound. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：519 / 520

页数：2