CONDITIONS REQUIRED FOR THE BACTERICIDAL ACTIVITY OF FLEROXACIN AND PEFLOXACIN AGAINST ESCHERICHIA-COLI KL16

被引：14

作者：

LEWIN, CS

AMYES, SGB

机构：

来源：

JOURNAL OF MEDICAL MICROBIOLOGY | 1990年 / 32卷 / 02期

关键词：

D O I：

10.1099/00222615-32-2-83

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Pefloxacin and fleroxacin showed biphasic bactericidal activity against Escherichia coli KL16 in nutrient broth. Bacteriostatic concentrations of chloramphenicol, an inhibitor of protein synthesis, and rifampicin, an inhibitor of RNA synthesis, could not completely abolish the bactericidal activity of either drug. Pefloxacin and fleroxacin were also active against no-dividing E. coli KL16. Therefore, pefloxacin and fleroxacin are able to kill bacteria which are not dividing nor actively synthesising protein or RNA.

引用

页码：83 / 86

页数：4

共 14 条

[1]

BERGAN T, 1988, QUINOLONES, P23

[2]

DIETZ WH, 1966, J BACTERIOL, V91, P768

[3] PEFLOXACIN - A REVIEW OF ITS ANTIBACTERIAL ACTIVITY, PHARMACOKINETIC PROPERTIES AND THERAPEUTIC USE [J].