SPECIFIC ANTIBODIES AGAINST THE STRESS-INDUCIBLE 72-KDA PROTEIN, A MEMBER OF THE HEAT-SHOCK PROTEIN HSP70, IN HEALTHY-HUMAN SUBJECTS

被引：27

作者：

WAKUI, H

ITOH, H

TASHIMA, Y

KOBAYASHI, R

NAKAMOTO, Y

MIURA, AB

机构：

[1] AKITA UNIV,SCH MED,DEPT BIOCHEM,AKITA 010,JAPAN

[2] NAGOYA UNIV,SCH MED,DEPT PHARMACOL,NAGOYA,AICHI 466,JAPAN

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY | 1991年 / 23卷 / 10期

关键词：

D O I：

10.1016/0020-711X(91)90132-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. On Western blot analysis, serum IgG from a healthy human subject reacted with a stress-induced protein, having an apparent molecular mass of 70 kDa, from PC12 cells. 2. This serum IgG also reacted with hsp70 (70-kDa heat-shock protein) purified from the bovine brain. 3. In 5 out of 34 healthy human subjects, IgG antibodies against hsp70 were detected. 4. These antibodies were directed against the stress-inducible 72-kDa protein, but did not cross-react with the constitutive 73-kDa protein.

引用

页码：975 / 978

页数：4

共 18 条

[1] ESTABLISHMENT OF A NORADRENERGIC CLONAL LINE OF RAT ADRENAL PHEOCHROMOCYTOMA CELLS WHICH RESPOND TO NERVE GROWTH-FACTOR [J].