LOCAL ENKEPHALINS TONICALLY MODULATE DOPAMINE RELEASE IN THE STRIATUM - A MICRODIALYSIS STUDY

被引：31

作者：

DOURMAP, N

MICHAELTITUS, A

COSTENTIN, J

机构：

[1] UFR MED & PHARM ROUEN, CNRS,UA 1170,UNITE NEUROPHARMACOL EXPTL,AVE UNIV, BP 97, F-76803 ST ETIENNE DU ROUVRAY, FRANCE

[2] UNIV LONDON, QUEEN MARY & WESTFIELD COLL, SCH BIOL SCI, LONDON, ENGLAND

来源：

BRAIN RESEARCH | 1990年 / 524卷 / 01期

关键词：

Dopamine release; Endogenous enkephalin; Enkephalin-degrading peptidase; Kelatorphan; Microdialysis; Rat striatum;

D O I：

10.1016/0006-8993(90)90505-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Kelatorphan, an inhibitor of the enkephalin-degrading enzymes, infused by microdialysis (10-6 M) in the striatum of anaesthetized rats, significantly increased dopamine (DA) output but left dihydroxyphenylacetic acid and homovanillic acid extracellular levels unchanged. The local application of naltrexone (10-6 M) prevented the effect of kelatorphan on DA release. These data indicate that local enkephalins tonically modulate DA release in rat striatum. © 1990.

引用

页码：153 / 155

页数：3

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