GROWTH AND SOLVENT-MEDIATED PHASE-TRANSITION OF CIMETIDINE POLYMORPHIC FORM-A AND FORM-B

被引:15
作者
SUDO, S
SATO, K
HARANO, Y
机构
[1] Department Of Applied Chemistry, Faculty Of Engineering, Osaka City University
[2] Dept. of food Sci and Technol, Fac. of Eng. Univ., Fukuyama
关键词
CRYSTALLIZATION; POLYMORPHISM; GROWTH RATE; PHASE TRANSITION; SEED EFFECT;
D O I
10.1252/jcej.24.628
中图分类号
TQ [化学工业];
学科分类号
0817 ;
摘要
For the organic compound cimetidine, which has seven polymorphic forms, the growth rates of form A (metastable) and B (stable) and the solvent-mediated phase transition rates from A to B were measured in 2-propanol solvent. At high supersaturation ratio (S(C,A) = 3.6), with form-A seed, agglomerated crystals of form A were obtained without an induction period. With form-B seed, by contrast, form A nucleated heterogeneously on B seed's surface and then grew to single-like crystals after the induction period. At low supersaturation ratio (S(A) less-than-or-equal-to 1.3, S(B) less-than-or-equal-to 1.7), the growth rate of form A was higher than that of form B at the same supersaturation ratio, S(i), based on their respective solubilities, but at the same solute concentration this tendency was reversed. At S(A) = 1.0, a solvent-mediated phase transition took place, being controlled by the growth rate of form B. The growth rates of both forms at low supersaturation were proportional to the surface area of crystal and (S(i) - 1)2.
引用
收藏
页码:628 / 632
页数:5
相关论文
共 7 条
[1]  
Bavin P. M. G., 1976, Patent GB, Patent No. [1 543 238 (A), 1543238]
[2]   CIMETIDINE - NON-THIOUREA H2-RECEPTOR ANTAGONIST [J].
BRIMBLECOMBE, RW ;
DUNCAN, WAM ;
DURANT, GJ ;
EMMETT, JC ;
GANELLIN, CR ;
PARSONS, ME .
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 1975, 3 (02) :86-92
[3]   THE KINETICS OF SOLVENT-MEDIATED PHASE-TRANSFORMATIONS [J].
CARDEW, PT ;
DAVEY, RJ .
PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON SERIES A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES, 1985, 398 (1815) :415-428
[4]  
HARANO Y, 1985, APPLIED PHYSICAL CHE, P11
[5]   THE POLYMORPHISM OF CIMETIDINE [J].
HEGEDUS, B ;
GOROG, S .
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1985, 3 (04) :303-313
[6]  
PRODICKOJIC B, 1979, GAZZ CHIM ITAL, V109, P535
[7]   SOLUBILITIES AND CRYSTALLIZATION BEHAVIOR OF CIMETIDINE POLYMORPHIC FORM-A AND FORM-B [J].
SUDO, S ;
SATO, K ;
HARANO, Y .
JOURNAL OF CHEMICAL ENGINEERING OF JAPAN, 1991, 24 (02) :237-242