ALKALOIDS OF DELPHINIUM-CASHMIRIANUM

Dephinium cashmirianum Royle (Ranunculaceae) has yielded the new base eashmiradelphine (12), together with the known alkaloids anthranoyllycoctonine (9), lycaconitine (15), avadharidine (17), lappaconitine (4), and A'-deacetyllappaconitine (7). Pyridinium chlorochromate oxidation of lycoctonine furnished the new aldehyde lycoctonal (11). The arrhythmogenic and heart rate effects of several of these diterpenoidal alkaloids have been measured on the isolated guinea atria. Lappaconitine was arrhythmogenic at 1CMM concentrations. But in contrast to the reference drug aconitine, lappaconitine did not increase the hearx rate. In anesthetized rabbits injected with lappaconitine, A'-deacetyllappaconitine, and lappaconine up to 1 mg'kg, cardiac arrhythmia was quickly observed. Even up to 5 mg kg, the other substances were non-arrhythmogenic. © 1979, American Chemical Society. All rights reserved.