URINARY CRYSTAL-SURFACE BINDING SUBSTANCES ON CALCIUM-OXALATE CRYSTALS

被引：24

作者：

KOIDE, T ^{[1
]}

YOSHIOKA, T ^{[1
]}

YAMAGUCHI, S ^{[1
]}

HOSOKAWA, S ^{[1
]}

UTSUNOMIYA, M ^{[1
]}

SONODA, T ^{[1
]}

机构：

[1] OSAKA UNIV,SCH MED,DEPT UROL,OSAKA,JAPAN

来源：

UROLOGICAL RESEARCH | 1990年 / 18卷 / 06期

关键词：

Adsorption; Calcium oxalate; Crystal surface; Crystallization; Glycoprotein; Inhibitors;

D O I：

10.1007/BF00297370

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

In order to study the effect of urinary crystal surface binding substances (CSBS), we extracted the naturally existing CSBS from urine from healthy individuals by conducting homogeneous crystallization of calcium oxalate. CSBS proved not to be promoters but rather strong inhibitors of calcium oxalate crystal growth and aggregation. It is suggested that CSBS exhibited their inhibitory effect by masking the growing sites and aggregating sites on the crystal surface. As for the characteristics of CSBS, we found around 10 peaks of molecular weight, and all of them contained both peptides and saccharides. The findings suggest that CSBS are composed of various kinds of glycoproteins and proteoglycans. © 1990 Springer-Verlag.

引用

页码：387 / 392

页数：6

共 28 条

[1] SURFACE INTERACTION BETWEEN GLYCOSAMINOGLYCANS AND CALCIUM-OXALATE [J].