ASYMMETRIC ALKYLATIONS ON CHIRAL FORMAMIDINES - MOLECULAR MECHANICS STUDIES RELATING TO THE FACIAL SELECTIVITY OF THE LITHIATED INTERMEDIATES

被引：10

作者：

CASTONGUAY, LA ^{[1
]}

GUILES, JW ^{[1
]}

RAPPE, AK ^{[1
]}

MEYERS, AI ^{[1
]}

机构：

[1] COLORADO STATE UNIV,DEPT CHEM,FT COLLINS,CO 80523

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1992年 / 57卷 / 14期

关键词：

D O I：

10.1021/jo00040a019

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Molecular mechanics studies on the lithiated chiral formamidines 1 and 3 provide an explanation for the observed degree of facial selectivity during alkylation. The energetic origin of the conformers which predominate prior to each alkylation step are found visibly to arise from angle strain and H-H repulsions.

引用

页码：3819 / 3821

页数：3

共 14 条

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