ASYMMETRICAL EFFECTS OF CORTICAL ABLATION ON BRAIN MONOAMINES IN MICE

Neurochemical changes induced by right or left cortical ablation which have previously been described to have immunological effects were investigated in mice. Catecholamine and indolamine levels were determined in the contralateral cortex and in subcortical structures involved in immunoregulation 14 and 60 days after unilateral cortical ablation. Unilateral cortical ablation induced profound and widespread changes in the contralateral cortex but also in subcortical regions of both sides at 14 days after surgery. Lesions of the left neocortex appeared mainly to affect the activity of serotoninergic inputs to the right neocortex, whereas ablations of the right cortex influenced the activity of the catecholaminergic inputs to the left. Sixty days after surgery, modications in monoamine levels were observed only in the ipsilateral, but not contralateral, subcortical regions, the only exception being that DA turnover in the tuberoinfun-dibular system remained lowered in both hemispheres after either right or left cortical ablations. Furthermore, some asymmetrical effects of cortical lesions depended on functional brain lateralization as assessed by paw preference. It may be hypothesized that some neurochemical modifications induced by unilateral cortical lesions are, at least partially, responsible for the immunological perturbations observed after cortical ablation. © 1991 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.