THE USE OF ISOLATED MYOCYTES TO EVALUATE MYOCARDIAL REMODELING

被引：30

作者：

GERDES, AM ^{[1
]}

机构：

[1] UNIV S FLORIDA, DEPT MED, TAMPA, FL 33612 USA

来源：

TRENDS IN CARDIOVASCULAR MEDICINE | 1992年 / 2卷 / 04期

关键词：

D O I：

10.1016/1050-1738(92)90023-L

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

It has been postulated that changes in the gross anatomic features of the heart due to various hemodynamic alterations (for example, pressure or volume overloading) are mirrored by specific changes in myocyte shape. The development of the isolated cardiac myocyte preparation has been instrumental in providing a more consistent and expeditious means for assessing changes in cellular dimensions. Data obtained from isolated myocytes collected from adult rats with various types of hemodynamic overloading confirm that cell shape changes in a consistent and predictable manner and that hypertrophy, rather than hyperplasia, is responsible for the increase in cardiac mass. The use of isolated myocytes should provide answers to many other questions regarding ventricular remodeling.

引用

页码：152 / 155

页数：4

共 26 条

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