EFFECT OF DEXFENFLURAMINE ON ALCOHOL INTAKE IN ALCOHOL-PREFERRING P-RATS

被引：20

作者：

ROWLAND, NE

MORIAN, KR

机构：

[1] Department of Psychology, University of Florida, Gainesville

来源：

ALCOHOL | 1992年 / 9卷 / 06期

关键词：

DEXFENFLURAMINE; ETHANOL; P-RAT; SEROTONIN;

D O I：

10.1016/0741-8329(92)90097-T

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

The intake of alcohol, in 2-h daily sessions, by the preferring (P) line of rats was reduced in a dose-related manner by acute subcutaneous (SC) administration of dexfenfluramine (DFEN). Ad lib intake of alcohol was reduced by chronic SC administration of DFEN. The effective doses and magnitude of effects of DFEN on alcohol intake are comparable to those previously reported for DFEN anorexia. Because DFEN anorexia is related to increased brain serotonin (5HT) activity, its effect on alcohol consumption may also be via 5HT.

引用

收藏

页码：559 / 561

页数：3

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