FACILE FORMATION OF A CIS-PLATIN-NONAPEPTIDE COMPLEX OF HUMAN DNA POLYMERASE-ALPHA ORIGIN

被引：19

作者：

BOSE, RN ^{[1
]}

LI, DW ^{[1
]}

KENNEDY, M ^{[1
]}

BASU, S ^{[1
]}

机构：

[1] UNIV NOTRE DAME,DEPT CHEM & BIOCHEM,NOTRE DAME,IN 46556

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1995年 / 17期

关键词：

D O I：

10.1039/c39950001731

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

cis-DDP readily forms a complex with a nonapeptide, E R F K C P C P T, selected from near the DNA binding domain of human DNA polymerase-alpha, through the two cysteine residues; the reaction is more than an order of magnitude faster than that for the cis-DDP and DNA reaction.

引用

页码：1731 / 1732

页数：2

共 29 条

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