AMINOACYL-RNA SYNTHESIS CATALYZED BY AN RNA

被引：273

作者：

ILLANGASEKARE, M

SANCHEZ, G

NICKLES, T

YARUS, M

机构：

[1] Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder

来源：

SCIENCE | 1995年 / 267卷 / 5198期

关键词：

D O I：

10.1126/science.7530860

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

An RNA has been selected that rapidly aminoacylates its 2'(3') terminus when provided with phenylalanyl-adenosine monophosphate. That is, the RNA accelerates the same aminoacyl group transfer catalyzed by protein aminoacyl-transfer RNA synthetases. The best characterized RNA reaction requires both Mg2+ and Ca2+. These results confirm a necessary prediction of the RNA world hypothesis and represent efficient RNA reaction (greater than or equal to 10(5) times accelerated) at a carbonyl carbon, exemplifying a little explored type of RNA catalysis.

引用

页码：643 / 647

页数：5

共 28 条

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