MIDA1, A PROTEIN ASSOCIATED WITH ID, REGULATES CELL-GROWTH

被引：76

作者：

SHOJI, W ^{[1
]}

INOUE, T ^{[1
]}

YAMAMOTO, T ^{[1
]}

OBINATA, M ^{[1
]}

机构：

[1] TOHOKU UNIV,INST DEV AGING & CANC,DEPT CELL BIOL,AOBA KU,SENDAI,MIYAGI 98077,JAPAN

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 1995年 / 270卷 / 42期

关键词：

D O I：

10.1074/jbc.270.42.24818

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have isolated cDNA clone encoding a protein that can associate with Id, a helix-loop-helix (HLH) protein, This protein is named MIDA1 (mouse Id associate 1), and its predicted amino acid sequence consists of Zuotin (a putative Z-DNA binding protein in yeast) homology region and tryptophan-mediated repeats similar to c-Myb oncoprotein. MIDA1 associates with the HLH region of Id with the conserved region adjacent to eukaryotic DnaJ conserved motif within the Zuotin homology region, although it does not have any canonical HLH motif. The addition of antisense oligonucleotide of MIDA1 inhibited growth of murine erythroleukemia cells without interfering with erythroid differentiation, indicating that it regulates cell growth.

引用

页码：24818 / 24825

页数：8

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