ENZYMATIC AND IMMUNOLOGIC INHIBITORS OF PROTEASES IN CSF

The CSF contains the same protease-inhibiting globulins as the serum: α1-antitrypsin, inter-α-trypsin inhibitor and α2-macroglobulin. These inhibitors can be determined either by enzymatic methods, which utilise inhibition of trypsin an chymotrypsin, or by electro-immunodiffusion with specific antisera. CSF inhibitor concentrations are generally one hundred times lower than those of normal serum. More than half of the liquids studied contained no α2-macroglobulin. © 1969.