CROSS-REACTION IN ALLERGIC CONTACT-DERMATITIS FROM ALPHA-METHYLENE-GAMMA-BUTYROLACTONES - IMPORTANCE OF THE CIS OR TRANS RING JUNCTION

被引：14

作者：

SCHAEFFER, M

TALAGA, P

STAMPF, JL

BENEZRA, C

机构：

[1] Laboratoire de Dermatochimie, Université Louis Pasteur, Clinique Dermatologique CHU de Strasbourg, Strasbourg

来源：

CONTACT DERMATITIS | 1990年 / 22卷 / 01期

关键词：

bicyclic lactones; cis or trans ring junctions; cross‐sensitivity; guinea pig sensitization; modifies FCAT method; sesquiterpene lactones; stereospecificity; α‐methylene‐γ‐butyolactones;

D O I：

10.1111/j.1600-0536.1990.tb01502.x

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Cross‐reaction in allergic contact dermatitis (ACD) is a highly stereoselective process. The importance of the cis or trans ring junction in α‐methylene‐γ‐butyrolactones in cross‐reactivity was investigates by reacting Helenin® (mostly a mixture of natural allergenic sesquiterpene lactones alantolactone 1 and isoalantolactone 2, which present a cis ring junction) in guinea pigs sensitized to model allergenic α‐methylene‐γ‐butyolactones: cis‐bicyclin lactone 3 and trans‐bicycle lactone 4. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：32 / 36

页数：5

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