QUANTITATIVE THIN-LAYER CHROMATOGRAPHIC MEASUREMENT OF N-TRIFLUOROACETYLADRIAMYCIN-14-VALERATE (AD-32) AND TRIFLUOROACETYLADRIAMYCIN (AD-41) IN BLOOD AND TISSUES

被引：10

作者：

BARBIERI, B ^{[1
]}

ABBRUZZI, R ^{[1
]}

BENIGNI, A ^{[1
]}

RIZZARDINI, M ^{[1
]}

DONELLI, MG ^{[1
]}

GARATTINI, S ^{[1
]}

SALMONA, M ^{[1
]}

机构：

[1] IST RIC FARMACOL MARIO NEGRI, VIA ERITREA 62, I-20157 MILAN, ITALY

来源：

JOURNAL OF CHROMATOGRAPHY | 1979年 / 163卷 / 02期

关键词：

D O I：

10.1016/S0378-4347(00)81463-2

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

TLC method was developed for the detection and measurement of N-trifluoroacetyladriamycin-14-valerate (AD 32) [an antitumor agent] and its major metabolite trifluoroacetyladriamycin (AD 41). The procedure gives satisfactory linearity over a large range of concentrations. The coefficient of variability is about 10% over the entire range of usable concentrations, giving good reproducibility; sensitivity is 25 ng for both AD 32 and AD 41. Analysis is specific for AD 32 and AD 41 since adriamycin or more polar metabolites can be differentiated. Recovery is high (85-90%) and the method is simple and economical to use. Pharmacokinetics of AD 32 and AD 41 are reported in blood and some tissues of mice bearing Lewis Lung carcinoma.

引用

页码：195 / 200

页数：6

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