MECHANISM OF AGGRAVATION OF INDOMETHACIN-INDUCED GASTRIC-ULCERS BY ADRENALECTOMY IN THE RAT

被引：29

作者：

URUSHIDANI, T ^{[1
]}

KASUYA, Y ^{[1
]}

OKABE, S ^{[1
]}

机构：

[1] KYOTO COLL PHARM,DEPT APPL PHARMACOL,YAMASHINA KU,KYOTO 607,JAPAN

来源：

JAPANESE JOURNAL OF PHARMACOLOGY | 1979年 / 29卷 / 05期

关键词：

D O I：

10.1254/jjp.29.775

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

Bilateral adrenalectomy markedly aggravated gastric ulcers in rats induced by 5 or 20 mg/kg of indomethacin. The degree of aggravation was much the same in experiments done 1 and 14 days after operation. Pretreatment with prednisolone 10 mg/kg or cortisone acetate 10 mg/kg given subcutaneously significantly suppressed the aggravated ulceration in response to 20 mg/kg of indomethacin in these adrenal ectomized rats. Desoxycorticosterone acetate 10 mg/kg, however, had no effect on the aggravation of indomethacin-induced ulcers. Epinephrine 0.1 or 1 mg/kg given subcutaneously markedly suppressed the indomethacin-induced ulcers in adrenal ectomized rats. Removal of the adrenal medulla alone did not appreciably influence the development of indomethacin-induced ulcers. These results indicate that the adrenal cortex, particularly the area containing glucocorticoids, plays an important role in suppression of the noxious effect of indomethacin on the rat gastric mucosa. © 1979, The Japanese Pharmacological Society. All rights reserved.

引用

页码：775 / 780

页数：6

共 11 条

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