A NOVEL BRADYKININ ANTAGONIST WITH IMPROVED PROPERTIES

被引：27

作者：

LAMMEK, B

WANG, YX

GAVRAS, I

GAVRAS, H

机构：

[1] BOSTON CITY HOSP,THORNDIKE MEM LAB,DEPT MED,HYPERTENS SECT,BOSTON,MA 02118

[2] BOSTON UNIV HOSP,SCH MED,DEPT MED,BOSTON,MA 02218

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1991年 / 43卷 / 12期

关键词：

D O I：

10.1111/j.2042-7158.1991.tb03205.x

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

Acylation of the N-terminus of [D-Arg0, Hyp3, Thi5,8, D-Phe7] bradykinin with I-adamantanecarboxylic acid results in an analogue with enhanced potency of at least 33-fold. The new antagonist has potential as a pharmacological tool in the investigation of the role of endogenous bradykinin in cardiovascular regulation.

引用

页码：887 / 888

页数：2

共 7 条

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[3]

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[6]

STEWART JM, 1991, BRADYKININ ANTAGONIS, P51

[7]

[No title captured]

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