THE LIPOPHOSPHOGLYCAN OF LEISHMANIA AND MACROPHAGE PROTEIN-KINASE-C

被引：57

作者：

DESCOTEAUX, A

TURCO, SJ

机构：

[1] Department of Biochemistry, University of Kentucky Medical Center, Lexington

来源：

PARASITOLOGY TODAY | 1993年 / 9卷 / 12期

基金：

美国国家卫生研究院; 英国医学研究理事会;

关键词：

D O I：

10.1016/0169-4758(93)90105-O

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Lipophosphoglycan (LPG), the major cell-surface glycoconjugate of Leishmania promastigotes, is an essential virulence determinant. One feature of LPG resides in its strong inhibitory effect on the activity of purified protein kinase C (PKC). In this article, Albert Descoteaux and Salvatore Turco briefly review the evidence that LPG effectively inhibits PKC activity in the macrophage, and discuss the implication of such inhibition on Leishmania intramacrophage survival.

引用

页码：468 / 471

页数：4

共 38 条

[1] MOLECULAR TRANSDUCTIONAL MECHANISMS BY WHICH IFN-GAMMA AND OTHER SIGNALS REGULATE MACROPHAGE DEVELOPMENT [J].