NEUROMUSCULAR BLOCKING-AGENTS - APPROACHES TO SHORT-ACTING COMPOUNDS .2. BIS-THIAZOLIUM SALTS

被引：10

作者：

STENLAKE, JB ^{[1
]}

DHAR, NC ^{[1
]}

HENDERSON, CF ^{[1
]}

MAEHR, RB ^{[1
]}

SCHARVER, J ^{[1
]}

WASTILA, WB ^{[1
]}

MIDGLEY, JM ^{[1
]}

机构：

[1] BURROUGHS WELLCOME CO,WELLCOME RES LABS,RES TRIANGLE PK,NC 27709

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1993年 / 28卷 / 05期

关键词：

QUATERNARY AMMONIUM COMPOUNDS; BIS-THIAZOLIUM SALTS; NEUROMUSCULAR BLOCKING AGENTS;

D O I：

10.1016/0223-5234(93)90128-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of bis-thiazolium diesters has been prepared. All were substantially less potent than atracurium and all showed appreciable vagal blockade at neuromuscular blocking doses. N-Benzyl quaternary substituents shortened the duration of neuromuscular blockade significantly. Neuromuscular blocking potency was greater and duration of action least in bis-N-3,4,5-trimethoxybenzylthiazolium salts, though each of these effects was at its optimum at differing interquaternary chain separations.

引用

页码：415 / 418

页数：4

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