The crucial roles of inflammatory mediators in inflammation: A review

被引：548

作者：

Abdulkhaleq, L. A. ^{[1
,2
]}

Assi, M. A. ^{[3
,4
]}

Abdullah, Rasedee ^{[5
]}

Zamri-Saad, M. ^{[5
]}

Taufiq-Yap, Y. H. ^{[6
]}

Hezmee, M. N. M. ^{[4
]}

机构：

[1] Baghdad Univ, Fac Vet Med, Dept Pathol & Poultry Dis, Baghdad, Iraq

[2] Univ Putra Malaysia, Fac Vet Med, Dept Vet Pathol & Microbiol, Serdang, Malaysia

[3] Al Furat Al Awsat Tech Univ, Dept Community Hlth, Coll Hlth & Med Tech, Kufa, Najaf Governara, Iraq

[4] Univ Putra Malaysia, Dept Vet Preclin Sci, Fac Vet Med, Serdang, Malaysia

[5] Univ Putra Malaysia, Dept Vet Lab Diagnost, Fac Vet Med, Serdang, Malaysia

[6] Univ Putra Malaysia, Fac Sains, Dept Chem, Serdang, Malaysia

来源：

VETERINARY WORLD | 2018年 / 11卷 / 05期

关键词：

chemokines; cytokines; inflammatory mediators; inflammatory response;

D O I：

10.14202/vetworld.2018.627-635

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 [畜牧学];

摘要：

The inflammatory response is a crucial aspect of the tissues' responses to deleterious inflammogens. This complex response involves leukocytes cells such as macrophages, neutrophils, and lymphocytes, also known as inflammatory cells. In response to the inflammatory process, these cells release specialized substances which include vasoactive amines and peptides, eicosanoids, proinflammatory cytokines, and acute-phase proteins, which mediate the inflammatory process by preventing further tissue damage and ultimately resulting in healing and restoration of tissue function. This review discusses the role of the inflammatory cells as well as their by-products in the mediation of inflammatory process. A brief insight into the role of natural anti-inflammatory agents is also discussed. The significance of this study is to explore further and understand the potential mechanism of inflammatory processes to take full advantage of vast and advanced anti-inflammatory therapies. This review aimed to reemphasize the importance on the knowledge of inflammatory processes with the addition of newest and current issues pertaining to this phenomenon.

引用

页码：627 / 635

页数：9

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