CRYSTAL-STRUCTURE ANALYSIS OF THE DESOLVATION OF THE CHLOROFORM SOLVATE OF GRISEOFULVIN

被引：16

作者：

CHENG, KC ^{[1
]}

SHEFTER, E ^{[1
]}

SRIKRISHNAN, T ^{[1
]}

机构：

[1] SUNY BUFFALO, SCH PHARM, DEPT PHARMACEUT, AMHERST, NY 14260 USA

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1979年 / 2卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0378-5173(79)90051-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The crystal structures of the chloroform solvate and a non-solvated form of griseofulvin were determined by X-ray diffraction methods. There are substantial differences in the packing arrangements of the two forms. The chloroform molecules in the solvate are arranged in layers perpendicular to the c-axis. This dictates the direction which the solvent can exit from the crystal. © 1979.

引用

页码：81 / 89

页数：9

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[4]

SEKIGUCHI K, 1968, CHEM PHARM BULL, V16, P2495

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