RISK OF CANCER DEATH IN 1ST-DEGREE RELATIVES OF PATIENTS WITH HEREDITARY NONPOLYPOSIS CANCER SYNDROME (LYNCH TYPE-II) - A STUDY OF 130 KINDREDS IN THE UNITED-KINGDOM

被引：56

作者：

ITOH, H

HOULSTON, RS

HAROCOPOS, C

SLACK, J

机构：

[1] ROYAL FREE HOSP,SCH MED,DEPT CLIN GENET,LONDON NW3 2QG,ENGLAND

[2] ST MARKS HOSP,LONDON EC1V 2PS,ENGLAND

来源：

BRITISH JOURNAL OF SURGERY | 1990年 / 77卷 / 12期

关键词：

HEREDITARY NONPOLYPOSIS COLON CANCER; HNPCC; DOMINANT INHERITANCE; RELATIVE RISKS;

D O I：

10.1002/bjs.1800771216

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

To estimate the relative risks of cancer in first-degree relatives of index patients, 130 pedigrees of dominantly inherited Lynch type II cancer family syndrome have been analysed. The risk of death from all causes was significantly increased in women over 45 years of age and the overall liability to cancer in women was greater than for men. A sevenfold increase in risk of colon cancer was found in both sexes. In female relatives the risk of breast cancer was increased fivefold and lifetime risk of breast cancer was 1 in 3.7. A screening programme based on estimated risks could be offered to first-degree relatives of index patients with Lynch type II cancer family syndrome.

引用

页码：1367 / 1370

页数：4

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